Regional distribution center of logistics system provides the service of assembling, packaging and shipping products to customers. The center has to minimize the product inventory, in-transit materials, and components meet the dynamic demands according to the market changes. So, for the regional distribution centers in market-oriented enterprises, an efficient distribution operation plan method is needed desperately. However, there are fewer literatures about the feature development method of a regional distribution center dealing with sales and distribution planning models. Therefore, this study takes maximizing customer satisfaction as the point of view with consideration of time urgency and product value of the delivery coordinated with regional distribution center distribution planning method. Finally, the empirical case studies are applied to illustrate and validate this method deciding the distribution route and compare the performance difference on the planning result by two different core formulas.