This paper develops an assessment framework of national quality infrastructure efficacy (NQIE) which represents a new quality management paradigm for stakeholders and quality managers. The basis is to decompose the complex concept of NQIE into several portions and then integrate portions together with multi-criteria decision analysis method to assess NQIE. The constructed NQIE assessment framework was applied to a case study in Zhejiang province, China for validation. The results showed that NQI construction in Zhejiang province had achieved great progress with continuous growth. Meanwhile, the contribution analysis of each attribute parameter to general NQIE can provide scientific basis for decision makers to recognize the most and least contributed parameters for general NQIE and therefore taking measures to improve NQIE.