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A work-loop calorimeter for measuring the force-length-heat relationship of working excised cardiac muscle fibers | IEEE Conference Publication | IEEE Xplore

A work-loop calorimeter for measuring the force-length-heat relationship of working excised cardiac muscle fibers


Abstract:

Isolated cardiac trabeculae are convenient specimens with which to study the properties of cardiac muscle under a variety of controlled conditions in vitro. We have devel...Show More

Abstract:

Isolated cardiac trabeculae are convenient specimens with which to study the properties of cardiac muscle under a variety of controlled conditions in vitro. We have developed an instrument for measuring the mechanical and energetic properties of continuously-superfused cardiac trabeculae. Our instrument is capable of dynamically transitioning between fixed-length, isometric and isotonic modes of control during the time-course of a muscle twitch, allowing us to impart force-length work-loops that mimic the behaviour of cardiac muscle in vivo. Simultaneously, sensitive temperature transducers quantify muscle heat production. The combination of these interventions and measurements yields unique insight into the energetic efficiency of living cardiac muscle.
Date of Conference: 30 August 2011 - 03 September 2011
Date Added to IEEE Xplore: 01 December 2011
ISBN Information:

ISSN Information:

PubMed ID: 22254702
Conference Location: Boston, MA, USA

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