This study provides the capability of mapping, monitoring distribution and changes of regional mangroves using remote sensing data. The study area located in Mekong delta, Vietnam. Landsat ETM+ and digital elevation model (DEM) were used to enhance the discrimination between mangrove and non-mangrove forests and MAD technique was used to assess the changes in the mangrove cover in study area. Results showed that information from satellite remote sensing can play a useful role in determining the changes in land area and mangrove cover in Mekong Delta, especially mangrove forests has been significantly reduced in Tra Vinh province during 2000-2005.