This paper summarizes a new investigation of applying advanced pansharpening algorithms to enhance the images of the left imager in the Mastcam onboard the Curiosity rover, which landed on Mars in 2012. The various instruments on the rover have already made great contributions in the understanding of Mars. The goal of our research is to generate both high spatial and high spectral image cube by using the left and right Mastcam imagers. Eleven algorithms have been investigated using five objective performance metrics. Subjective evaluations have also been conducted. The image enhancement results are encouraging.