This paper presents a new multi-class gene selection and classification method based on multiple support vector machine recursive feature elimination (SVM-RFE). For a multi-class DNA microarray problem, we solve it as multiple binary classification problems. First, the one-versus-all method is used to decompose the multi-class task into multiple binary problems. Second, an SVM-RFE is adopted to select genes for each binary problem. Then, an SVM classifier is used to train the selected gene data for a binary problem. Finally, we combine the outputs of multiple SVM classifiers. Experimental results on three DNA Microarray datasets show that the proposed method achieves higher classification accuracy.