In recent years, with the development of social networks, sentiment analysis has become one of the most important research topics in the field of natural language processing. The deep neural network model combining attention mechanism has achieved remarkable success in the task of target-based sentiment analysis. In current research, however, the attention mechanism is more combined with LSTM networks, such neural network- based architectures generally rely on complex computation and only focus on the single target, thus it is difficult to effectively distinguish the different polarities of variant targets in the same sentence. To address this problem, we propose a deep neural network model combining convolutional neural network and regional long short-term memory (CNN-RLSTM) for the task of target-based sentiment analysis. The approach can reduce the training time of neural network model through a regional LSTM. At the same time, the CNN-RLSTM uses a sentence-level CNN to extract sentiment features of the whole sentence, and controls the transmission of information through different weight matrices, which can effectively infer the sentiment polarities of different targets in the same sentence. Finally, experimental results on multi-domain datasets of two languages from SemEval2016 and auto data show that, our approach yields better performance than SVM and several other neural network models.