This paper explores the socio-economic aspects of human capital, especially the IT users' innovation capability in regional cross-border small and medium-sized enterprises in Poland and in Germany. Socio-economic aspects of human capital are crucial for the socioeconomic development that may be achieved through virtual access to online learning tools and by diagnosing IT users' innovation capability and their business competencies, in relation to information and communication technologies. This paper presents an initial report on experimental research that was conducted online using the author's diagnostic tools. Conclusions and findings of this work contribute to socioeconomic development of cross-border regions in both countries. This research fulfills the gap in the sphere of connecting simultaneously three aspects - research, learning, and practice for socioeconomic development of both countries.