Emerging spread spectrum high-speed data networks utilize multiple channels via orthogonal codes or frequency-hopping patterns such that multiple users can transmit concurrently. In this paper, we develop a framework for opportunistic scheduling over multiple wireless channels. With a realistic channel model, any subset of users can be selected for data transmission at any time, albeit with different throughputs and system resource requirements. We first transform selection of the best users and rates from a complex general optimization problem into a decoupled and tractable formulation: a multiuser scheduling problem that maximizes total system throughput and a control-update problem that ensures long-term deterministic or probabilistic fairness constraints. We then design and evaluate practical schedulers that approximate these objectives.