In this paper, we developed a sensor-integrated shoe as an information acquisition platform to sense the foot motion. The system is small, portable and wearable. The platform is mainly composed of four parts including a sensing module, a computing module, a wireless communication module, and a data visualization module. Based on this platform, we developed a novel input device called Shoe-Mouse, which can be used by people who have difficulties in using their hands to operate computers or devices. We evaluated the performance of Shoe-Mouse, and the initial experimental results demonstrated the function. The platform can be also used for applications such as gait recognition, human identification, and motion monitoring.