In 2D multislice MRI, the resolution in the slice direction is often worse than the in-plane resolution. For certain diagnostic imaging applications, isotropic resolution is necessary but true 3D acquisition methods are not practical. In this case, if the imaging volume is acquired two or more times, with small spatial shifts between acquisitions, combination of the data sets using an iterative superresolution algorithm gives improved resolution and better edge definition in the slice-select direction.