Direct estimation from list-mode data for reversible tracers using graphical modeling | IEEE Conference Publication | IEEE Xplore

Direct estimation from list-mode data for reversible tracers using graphical modeling


Abstract:

We propose a novel method to directly estimate parametric images from listmode PET data for reversible tracers based on an inhomogeneous Poisson process model. We use a r...Show More

Abstract:

We propose a novel method to directly estimate parametric images from listmode PET data for reversible tracers based on an inhomogeneous Poisson process model. We use a relative equilibrium graphical model, similar to the Logan plot, to linearize the problem. A static sinogram from time of tracer injection to the steady state is incorporated to improve the ill-conditioning of the estimation problem. Cramer-Rao analysis and Monte-Carlo simulation demonstrate that our method improves the conditioning of the estimation problem and provides higher contrast recovery and smaller standard deviation compared with a sinogram based direct estimation approach.
Date of Conference: 16-19 April 2015
Date Added to IEEE Xplore: 23 July 2015
Electronic ISBN:978-1-4799-2374-8

ISSN Information:

Conference Location: Brooklyn, NY, USA

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