We present a comparative review of two multichannel integrated neural interface technologies. The first integrated neural interface prototype performs simultaneous current-mode acquisition of 16 independent channels of redox currents ranging five orders of magnitude in dynamic range over four scales down to hundreds of picoamperes. The second neural interface acquires neural field potentials in microvolts to millivolts range on a 16times16-electrode microarray in voltage mode. Each microsystem features programmable gain amplifiers, tunable band filters, configurable sample-and-hold circuits, and is ready for external analog-to-digital conversion. The current-mode and voltage-mode neural interface prototypes have been experimentally validated in chemical and electrical neural activity monitoring respectively. Side-by-side quantitative comparison of the two neural interface technologies is given