This paper presents a compact and scalable architecture design of a multi-channel potentiostat. Utilizing a hybrid-multiplexed technique, the system is capable of driving multi-electrode array structures of large sizes with few readout channels. A 5-channel potentiostat with 80-electrode capability was fabricated into a portable 8.382×9.906 cm² PCB prototype using discrete components. It features a dynamic current range of 126dB and 3.3V single-supply operation. Controlled by a MATLAB graphical user interface, the system demonstrates realtime data acquisition and achieves similar performance to a commercial potentiostat based on electrochemical validation.