The newly proposed Leaky Sign Regressor Least Mean Fourth (LSRLMF) algorithm is used in a fixed-point interference canceller for ElectroCardioGram (ECG) Baseline Wander (BW) removal application. An upper bound for the LSRLMF algorithm step-size is also presented. The LSRLMF-based interference canceller is quantized using different types of loss of precision methods. Through rigorous simulations, the quantization bit depth required for the different parameters of the LSRLMF-based interference canceller is found to be 9-bits for the most effective ECG baseline wander removal.