In this paper, a soft IP core of LVDS (low-voltage differential signaling) receivers is proposed for multichannel ultrasound imaging systems or other applications. By careful cellbased design, a high-speed de-serializer is developed with control-able bit-shift and delay-adjustment operations. Moreover, using the proposed hybrid coarse-tune and two-level fine-tune schemes, a synchronization controller can perform efficient and robust multichannel LVDS signal synchronizing processes in cooperation with the de-serializer. The proposed LVDS IP core is synthesiz-able cell-based design, which is soft/portable to different circuit technology and system applications. Based on the proposed LVDS structure, four sets of 8-channel LVDS receivers were designed and implemented on a 32-channel FPGA-based ultrasound imag-ing platform. Integrated with the ultrasound AFE/HVFE (analog and high-voltage front-end) module, a throughput of 480 Mb/s per channel can be achieved for test patterns, 32-channel ultrasound image and color-Doppler display.