This paper introduced the characteristics of anti-radiation aircraft and the composition of its guidance system. Based on the aerodynamic parameters and actual flight data of a certain type of airplane, this paper established a mathematical model of direct lateral force control, and put forward a decoupling method for the system. The system employer a tracking method in the guidance of the aircraft and gave simulation results. The advantages of this system are quick response, high percentage of hits, strong wind-resistance ability and casualty effect.