Technology enhanced multicultural e-learning education with its multilingual specifics applied at South East European University is the focus of the discussion and analyses. The analyses and the developed strategy takes into account the University’s mission in achieving multicultural and multilingual education within the context of the Balkans, but also in a wider European and global context. A number of issues related to such a specific context of the University, such as its multilingual and multicultural environment influenced the developed strategy and its implementation plan. The implemented strategy and solution as well as experiences gained in the process led to a number of important results as outcomes and recommendations for similar initiatives.