Current advances in the research field of autonomous driving demand advanced simulation methods for testing and validation. By combining versatile foci of different simulations, we can provide an increased amount and diversity of realistic traffic scenarios, which are relevant to the development and verification of high level automated driving functions. The focus of the present paper is to propose a concept for realistic simulation scenarios, which is capable of running in different integration levels, from software- to vehicle-in-the-loop. Its application is demonstrated, exposing an experimental vehicle, which is used for autonomous driving development, to a traffic scenario with virtual vehicles on a real road network.