Virtual manufacturing is introduced to the production process of E-Blocks of computer disk drives, which mainly includes the technologies of digital modeling, computer simulation and structural optimization. The Secondary development technology of CAD (computer aided design) is used to improve the efficiency of digital modeling. The trial period is cut down after the FEM (finite element method) is applied to the process of experimental cutting tool and structural modal simulation. The intelligence of virtual manufacturing is improved by using the technology of CAM (Computer Aided Manufacturing), which includes the strategy manager and the machining process simulation. The application shows that the trial period of E-Blocks of Computer Disk Drives is shorten nearly 50% by introducing virtual manufacturing.