Tthe BSN 2016 meeting in the University of California at San Francisco (UCSF) Mission Bay conference center focused on neuroscience applications including stress and behavior monitoring and chronic disease management. Keynote presentations highlighted the use of pattern analysis and "smart shoes" to manage Parkinson’s disease, and bioengineering advances in detecting electrodermal activity at the wrist associated with epilepsy and psychologically stressful events. The themes of the conference are described. A workshop sponsored and organized by Friedrich Alexander University, Erlangen, previewed this theme of automated sensor-based mobility analysis for chronic disease management.