Ground-penetrating radar (GPR) profiling is the primary tool to provide detail information of the internal structure and characteristics inside a sand dune in the desert area. However, with the severe elevation change in a short horizontal distance and on the rugged and complex surface topography of the sand dunes, getting clear imaging of the internal structure of sand dunes from the GPR profiling is still a big challenge. The classic imaging technique such as the Kirchhoff migration has been applied to process GPR data on sand dunes, with limited success. The reverse-time migration (RTM) technique is the most advanced imaging technique that can handles GPR data acquired on rugged surface with severe topographic relief to generate subsurface structural images with high fidelity and has been tried to process GPR data on sand dunes. The results are encouraging, and the imaging quality is significantly improved. The finite-difference time-domain (FDTD) method is the major numerical tool for forward and backward continuations of the wave field during the RTM process. There are two aspects for using FDTD in RTM of GPR data on sand dunes still need improvement: the numerical scattering caused by the staircase approximation of the ground surface by using gridding in the Cartesian coordinate, and the negligence of the possible anisotropy of the electromagnetic material properties due to the calcareous cementation bedding inside a sand dune. In this paper, we develop the RTM algorithm based on the staggered grid FDTD that handles the rugged topographic surface by using the curvilinear coordinate, and the possible anisotropic radar wave velocity of the sand dune media. We first demonstrate the equivalency of the nonuniform, isotropic medium and the uniform, anisotropic medium for justifying using the uniform, anisotropic velocity in the RTM by synthetic modeling. Next, we validate our approach of using the synthetic data with the comparison of using the Cartesian coordinate ...