This letter is devoted to the layout reconstruction via the ultra-wideband (UWB) through-wall imaging radar under one single observation and simultaneously takes account of the real-time human indication. In the proposed framework, layout reconstruction is taken as the preprocessing, where a coherent processing interval consisting of several successive received echoes in the initial stage is first employed to construct a range-Doppler (RD) spectrum. Then, in the RD spectrum, a series of selected discrete Doppler frequency signals is used to form Doppler back projection (BP) images. Finally, in the Doppler BP image stack, we design a 3-D constant false alarm rate detector to extract the building layout. Once completed, the achieved layout as auxiliary information is fused with the simultaneous human indication. Through-wall experiments show that the proposed method can effectively extract the covered layout of multiple walls under one single view and accordingly provide strong support for the concealed human sensing.