Humanoid robots can imitate human behaviour and provide interactive services to humans due to their humanoid form, especially humanoid wheeled robots that can perform more complex tasks with the additional mobility. With the development of robotics technology, humanoid robots have been used increasingly in the domestic environment where the robot needs to interact with unknown environments. This requires the robot to have both the ability to track with high accuracy and the ability to comply with complex environments. It is known that the robots with impedance control can have a superior performance in terms of compliance with unknown contact environments. However, the mobility of humanoid robots with wheels complicates the dynamic model of robots, which makes the development of impedance control challenging. In this letter, a whole-body impedance control approach for humanoid wheeled robots is proposed, with fuzzy adaptive systems to compensate for the uncertain dynamics of the controlled system. This approach realizes safe interaction and compliant operation with unknown environments including humans. Additionally, the experimental results conducted on a humanoid wheeled robot illustrate the effectiveness of the proposed controller.