Abstract:
Due to applications in areas such as diagnostics and environmental safety, detection of molecules at very low concentrations has attracted recent attention. A powerful to...Show MoreMetadata
Abstract:
Due to applications in areas such as diagnostics and environmental safety, detection of molecules at very low concentrations has attracted recent attention. A powerful tool for this is Surface Enhanced Raman Spectroscopy (SERS) where substrates form localized areas of electromagnetic “hot spots” where the signal-to-noise (SNR) ratio is greatly amplified. However, at low concentrations hot spots with target molecules bound are rare. Furthermore, traditional detection relies on having uncontaminated sensor readings which is unrealistic in a real world detection setting. In this paper, we propose a Bayesian Non-negative Matrix Factorization (NMF) approach to identify locations of target molecules. The proposed method is able to successfully analyze the spectra and extract the target spectrum. A visualization of the loadings of the basis vector is created and the results show a clear SNR enhancement. Compared to traditional data processing, the NMF approach enables a more reproducible and sensitive sensor.
Date of Conference: 21-24 September 2014
Date Added to IEEE Xplore: 20 November 2014
Electronic ISBN:978-1-4799-3694-6