This Special Issue (SI) brings together academic and industrial researchers to discuss technical challenges and recent results related to intelligent networks in order to meet the demanding requirements for user experience, efficiency, and performance in a complex network environment, novel design, configuration, and optimization for communications and networking. In response to the Call for Papers, we received over 60 paper submissions. After a careful review process, 12 outstanding articles have been selected for this SI. The articles in this SI are classified into three categories: (1) Intelligent network resources management, optimization, and sharing at the edge; (2) Cognitive computing and AI assisting the Internet of Things; and (3) AI-assisted network security and applications. The articles are briefly summarized.