Advances in network architecture, enhancements in signaling protocols, provisioning of end-to-end QoS, worldwide seamless mobility, and flexible service provision are among the major research challenges toward next-generation wireless networks. The integration and interoperability of all these technologies, along with new truly broadband wireless innovations and intelligent user-oriented services will lead toward the so-called 4G wireless networks. In this article we identify the key issues of an innovative transparent IP radio access system that targets 4G networks.