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Tissue morphology controlled by micropatterning and self-assembly of vascular mesenchymal cells | IEEE Conference Publication | IEEE Xplore

Tissue morphology controlled by micropatterning and self-assembly of vascular mesenchymal cells


Abstract:

Creating patterns of constituent ingredients are essential for tissue regeneration. Using vascular mesenchymal cells (VMCs) which spontaneously aggregate into multicellul...Show More

Abstract:

Creating patterns of constituent ingredients are essential for tissue regeneration. Using vascular mesenchymal cells (VMCs) which spontaneously aggregate into multicellular structure, we demonstrate a MEMS-based method to direct the assembly of VMCs into desired tissue patterns. Incorporating the inherent chirality of VMCs revealed by micro-engineered substrates, differences in initial cell plating can be amplified into the formation of exquisite radial structures resembling the crosssectional structure of liver lobules. Furthermore, when cocultured with VMCs, vascular endothelial cells (ECs) tracked with the VMCs and formed a coherent radial pattern, indicating the applicability to heterotypical cell organization. We envision method has broad implications for building instructive microenvironment for tissue engineering.
Date of Conference: 07-10 April 2013
Date Added to IEEE Xplore: 18 July 2013
ISBN Information:
Conference Location: Suzhou, China

References

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