Abstract:
Creating patterns of constituent ingredients are essential for tissue regeneration. Using vascular mesenchymal cells (VMCs) which spontaneously aggregate into multicellul...Show MoreMetadata
Abstract:
Creating patterns of constituent ingredients are essential for tissue regeneration. Using vascular mesenchymal cells (VMCs) which spontaneously aggregate into multicellular structure, we demonstrate a MEMS-based method to direct the assembly of VMCs into desired tissue patterns. Incorporating the inherent chirality of VMCs revealed by micro-engineered substrates, differences in initial cell plating can be amplified into the formation of exquisite radial structures resembling the crosssectional structure of liver lobules. Furthermore, when cocultured with VMCs, vascular endothelial cells (ECs) tracked with the VMCs and formed a coherent radial pattern, indicating the applicability to heterotypical cell organization. We envision method has broad implications for building instructive microenvironment for tissue engineering.
Published in: The 8th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems
Date of Conference: 07-10 April 2013
Date Added to IEEE Xplore: 18 July 2013
ISBN Information: