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Hemi-Parkinsonian Rat Motor/Non-Motor Symptom Evaluation with Deep Brain Stimulation | IEEE Conference Publication | IEEE Xplore

Hemi-Parkinsonian Rat Motor/Non-Motor Symptom Evaluation with Deep Brain Stimulation


Abstract:

arkinson’s Disease can be modelled in rats to investigate the impact of dopamine loss. Unilateral lesions, using 6-OHDA, cause a degeneration of the dopaminergic neurons ...Show More

Abstract:

arkinson’s Disease can be modelled in rats to investigate the impact of dopamine loss. Unilateral lesions, using 6-OHDA, cause a degeneration of the dopaminergic neurons of the nigrostriatal pathway resulting in motor deficits. The experiments performed in this study aimed to compare the motor and non-motor behaviour of healthy rats vs. lesioned rats (PD). We also assessed the effect that deep brain stimulation (DBS) has on the animals’ locomotor activity. This paper covers the rotarod, open field, and cylinder tests, as well as sleep-awake analysis. The results of the rotarod test show that healthy rats are able to stay on the rod for longer than PD rats. The open field test revealed that PD rats spend more time freezing and close to walls or corners, whereas healthy and stimulated rats are more motivated to explore. In the cylinder test, during DBS, there is an increase in both right and left paw touches on the cylinder wall compared to pre- and post-DBS. It has also been shown that PD and control rats show different sleep patterns, further experiments could be helpful to better understand this difference.
Date of Conference: 20-23 March 2019
Date Added to IEEE Xplore: 20 May 2019
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Conference Location: San Francisco, CA, USA

References

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