Localized transmission with frequency hopping in E-UTRA uplink can avoid some drawbacks of distributed transmission and offer improved possibilities for the frequency diversity. However, it is difficult to find out a general hopping pattern applicable to various transmission bandwidths while keeping single carrier transmission at the same time. In this paper, a new RB (Resource Block) adaptive hopping method based on predefined pattern of intra/inter-TTI frequency hopping is proposed for E-UTRA uplink. The method that can keep single carrier transmission and avoid collisions is suitable for various transmission bandwidths. Simulation results show that the proposed hopping mode is effective.