The method of implementing TDC with FPGA carry chain is widely used, but the delay time of each TDC bin is greatly affected by the changes of operating temperature. At present, the commonly used methods can’t well fit the changing trend of each delay bin in long delay line under the influence of complex temperature changes. In this paper, a neural network calibration module based on MLP is proposed, in which 128 delay time data of delay line and corresponding temperature data transmitted to the host computer are used as training samples to establish MLP. When working, the delay time of each TDC bin can be given independently by knowing current temperature condition. Through experiments, the compensation of network calibration module on temperature changes is verified, and the network can be transplanted to different types of FPGA chips and run under various temperature changes. The TDC have a precision of 34ps.