Many animals rely on their sensitive olfaction to look for partners, mate, identify family members, and other daily activities. It's a shortcut to study the mobile robot's odor source location by simulating animals' olfactory behavior. In this paper, the odor gas distribution is simulated by Fluent software, and the mobile robot's odor source searching strategies are proposed. In actual indoor environment, the mobile robot integrates the gas sensor, wind sensors, ultrasonic sensor, and integrates multi optimal searching algorithms, which can choose the optimum search strategy according to the changing of the environment. For the mobile robot, an integrated control system, which includes environmental awareness, decision-making and planning, behavior control and enforcement function, is developed in this paper.