This paper aims at the design of guidance and control system for hypersonic morphing vehicle in flight of dive phase. The morphing mode of hypersonic morphing vehicle is designed and the aerodynamic model of hypersonic morphing vehicle is established by software. Based on the relative line-of-sight equations, a guidance and control model for hypersonic morphing vehicle of the dive flight is designed. In order to realize the flight mission, the integrated guidance and control method of the morphing vehicle is applied by using the block dynamic surface method and the lift is controlled by using the morphing characteristics of the vehicle. Through numerical simulation analysis, the effectiveness of the integrated method of guidance and control is verified and the requirements of hypersonic morphing vehicle in the dive phase are well fulfilled.