We are creating a serious game in Oncobiology that will allow the player to support clinical decisions with biological data, with the aim of promoting hypothesis-driven clinical research. Serious games are becoming an important subject of research as they are a tool with increasing potential to the acquisition of knowledge and training of skills. Physicians in general and oncologists in particular are in constant need for continuous learning. In cancer management, biology plays a crucial role, as new advancements from basic science are constantly being translated into clinical practice. This paper documents the development of the prototype of the Oncobiology Game.