Serious games have been and currently are used for multiple purposes other than just entertainment, such as education, healthcare or emergency management. This research presents game-design elements based on specific functional and professional requirements among which usability plays a key role. The aim of the research is to steer the direction towards a game-design framework for evidence-based clinical procedure libraries (eCPL). For context analysis and game-element presentation, a "serious application" example is shown to illustrate the improvement through game-design elements. A context analysis was required to select suitable game-design elements to target system usability and solve system design problems. The game-based context analysis addressed gamification themes and games that match those themes. The matching themes can be further analysed to find game-design elements to solve problems or enhance existing functions. The game-design elements found in this research include immersion, support for different roles, flow enhancement, visual enhancement, learning stages and experience level support, design for interactivity and progress.