Malware detection using Hardware Performance Counters (HPC) has emerged as a promising solution to improve the security of computing systems as a complement to antivirus software. Hardware-based malware detectors (HMD) use Machine Learning (ML) classifiers to detect malicious application patterns. The inputs to ML classifiers are low-level performance features known as HPCs, hardware-related activity data collected from a processor at run time to profile the low-level microarchitectural behavior of an application. This paper proposes malware detection using HPCs and machine learning classifiers and highlights the effectiveness of malware detection at run-time. We use ensemble learning techniques to improve the performance of the hardware-based malware detectors, which reduces the number of necessary micro-architectural events. This improves the processor's efficiency by eliminating the need to run an application several times since a processor can measure only 2 to 8 events at a cycle. We use 18 machine-learning models along with two ensemble learning methods to evaluate the mal ware detection performance. Creating a total of 144 different configurations by the factor of The experimental results show that the ensemble learning-based malware detection with 2 HPCs using the ensemble technique outperforms standard classifiers with 8 HPCs by up to 10%. It also matches the performance of standard ML-based detectors that use 16 HPCs while requiring only 4 HPCs, thereby enabling effective run-time malware detection.