We describe the Human Dynamic Clamp or virtual partner interaction paradigm—itself inspired by cellular neuroscience—which allows humans to interact in real time with avatars driven by empirically verified models of biological coordination such as the HKB and Jirsa-Kelso Excitator models of rhythmic and discrete movement behavior. The Human Dynamic Clamp allows one to explore the parameter spaces of interactional dynamics in a variety of different contexts as well as to produce some surprising emergent effects, including the possibility of relating 1st and 3rd person descriptions and their neural correlates.