Usability is a quality factor that pointed out as being one of the most important factors in the acceptance of software engineering systems by end users. This can be explained by the increasing number of studies addressing the integration of the usability evaluation at the development process. However, most of these proposals aim to drive the selection of adequate alternative transformation according to a set of usability requirements. This paper proposed an approach that considers the interactive systems generation process as a usability optimization problem by the model-driven engineering approach. The aims was to generate all possible concrete user interfaces from a given abstract user interface. Then, the usability optimization process selects the optimal concrete user interface for a specific context of use.