This paper presents a novel crosstalk reduction technique, non-overlapping transition encoding (NOTE), which significantly reduces negative effects due to crosstalk. We evaluate the performance of a bus encoded by using the NOTE scheme. Results are compared to those obtained from a standard bus and a bus utilizing shielding. Simulations are run for different bus lengths and optimized repeater sizing and wire segmentation using the FreePDK 45 nm library. Finally, the trade-off of the proposed technique is discussed.