Weapon system-of-systems development roadmap (WRM) is one of the tools to effectively assist the development planning of weapon system-of-systems. However, with the increasing scale of the weapon system-of-systems, the design of WRM will face complexity and uncertainty, and the traditional tools cannot effectively deal with the above problems. Based on this, this study proposes a multi-objective optimization-based WRM generation method. First, we transform the WRM design process into a capability-centered multi-scenario weapon portfolio optimization problem and consider the uncertainty of both weapon development requirements and the weapon development process in the modeling. Secondly, the multi-objective optimization algorithm and comprehensive evaluation method are used to solve the model. Finally, we verify the feasibility and rationality of the proposed method through simulation experiments, which can provide decision support for the design of WRM.