This paper investigates adaptive neural network filtering control for uncertain nonlinear systems with general model state and input quantization. The plants under consideration contain quantized states, quantized input, and unknown nonlinear system functions. A universal quantizer is established for both system states and control input. In the control design process, neural networks and the command filter are used to approximate the unknown nonlinear system functions and overcome the discontinuities of virtual control signals, respectively. A new command filtering-based control strategy is proposed using the backstepping design technique. It is testified that the proposed control approach can guarantee that the closed-loop signals are semi-global uniform ultimate boundedness. A simulation example is presented to further demonstrate our proposed scheme’s effectiveness. Note to Practitioners—This work is motivated by the quantized control problem for a class of nonlinear systems with state and input quantization. In modern control engineering applications, quantization plays a crucial role due to the prevalent use of digital processors that operate with finite precision arithmetic. It is valuable and inevitable to minimize information flow, reduce communication burden, and improve system security. However, quantization will introduce significant discontinuous characteristics and strong nonlinearity, which may decrease the system’s performance and even drive the closed-loop system to instability. This paper demonstrates how to use backstepping and adaptive control methods with command filter to complete controller design and deal with the quantization effects. Therefore, it provides a feasible approach for engineering applications.