A simultaneous and time-synchronized electrical bio-impedance plethysmography (BPG) sensor system is implemented for long-term, continuous, and non-invasive measurement of arterial pulse wave velocity (PWV). The proposed BPG sensor system electrically separates each ground plane of two BPG channels and controller, and the two different BPG channels are time-synchronized by the controller transmitting periodic pulse signal to the two BPG channels. Furthermore, net parasitic capacitance between the ground planes is minimized by removing isolated DC-DC converter, limiting the number of digital capacitive isolators, and adopting optimal layout of the ground planes. The proposed sensor system is integrated on 278cm² printed circuit board. The sensor system consumes 0.35 W/channel, and outstanding channel-to-channel isolation is expected by coupling factor performance of −77.7 dB. In addition, modified electrode configuration for BPG at chest drastically reduces baseline wandering by respiratory motion artifact, thereby further facilitating long-term, continuous, and non-invasive PWV measurement. As a result, long-term, continuous, and non-invasive PWV measurement more than 95 minutes is successfully performed to pave the way for developing pulse transit time (PTT)-based cuff-less blood pressure (BP) estimation technique.