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Miniature Magnetic Resonance Imaging System for in situ Monitoring of Bacterial Growth and Biofilm Formation | IEEE Journals & Magazine | IEEE Xplore

Miniature Magnetic Resonance Imaging System for in situ Monitoring of Bacterial Growth and Biofilm Formation


Abstract:

In situ monitoring of bacterial growth can greatly benefit human healthcare, biomedical research, and hygiene management. Magnetic resonance imaging (MRI) offers two key ...Show More

Abstract:

In situ monitoring of bacterial growth can greatly benefit human healthcare, biomedical research, and hygiene management. Magnetic resonance imaging (MRI) offers two key advantages in tracking bacterial growth: non-invasive monitoring through opaque sample containers and no need for sample pretreatment such as labeling. However, the large size and high cost of conventional MRI systems are the roadblocks for in situ monitoring. Here, we proposed a small, portable MRI system by combining a small permanent magnet and an integrated radio-frequency (RF) electronic chip that excites and reads out nuclear spin motions in a sample, and utilize this small MRI platform for in situ imaging of bacterial growth and biofilm formation. We demonstrate that MRI images taken by the miniature––and thus broadly deployable for in situ work––MRI system provide information on the spatial distribution of bacterial density, and a sequential set of MRI images taken at different times inform the temporal change of the spatial map of bacterial density, showing bacterial growth.
Published in: IEEE Transactions on Biomedical Circuits and Systems ( Volume: 18, Issue: 5, October 2024)
Page(s): 990 - 1000
Date of Publication: 23 February 2024

ISSN Information:

PubMed ID: 38393852

Funding Agency:


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