Pervasive computing requires to build systems every day more complex and heterogeneous. Smart devices must be able to carry on sensing and actuation alongside with computation and communication. As such, many different technologies must be packed within the same object. Digital HW and SW coexist with analog components and Micro-Electro-Mechanical systems capable of sensing and controlling the physical environment. For this reason, the design of such devices must rely on the integration of many different descriptions belonging to different design domains. The high-level of heterogeneity involved in the modeling phase of the system development makes harder the validation of the system functionality, since holistic system simulation would require the integration of many different simulators. In this article, we propose a set of automatic abstraction techniques for multi-disciplines analog components. Then, we define a scheduling strategy to integrate the execution of continuous-time analog sub-components with automatically abstracted models of the digital HW parts of the system. As a final result, the proposed methodology produces a C++ virtual platform providing a holistic simulation of complex and heterogeneous devices.