Fully homomorphic encryption (FHE) has become progressively more viable in the years since its original inception in 2009. At the same time, leveraging state-of-the-art schemes in an efficient way for general computation remains prohibitively difficult for the average programmer. In this work, we introduce a new design for a fully homomorphic processor, dubbed Juliet, to enable faster operations on encrypted data using the state-of-the-art TFHE and cuFHE libraries for both CPU and GPU evaluation. To improve usability, we define an expressive assembly language and instruction set architecture (ISA) judiciously designed for end-to-end encrypted computation. We demonstrate Juliet's capabilities with a broad range of realistic benchmarks including cryptographic algorithms, such as the lightweight ciphers Simon and Speck, as well as logistic regression (LR) inference and matrix multiplication.