We study the worst case response time (WCRT) analysis and evaluation for sporadic message-processing tasks in a multicore automotive gateway of a controller area network (CAN) cluster. We first build a multicore automotive gateway on CAN clusters. Two WCRT analysis methods for message-processing tasks in the multicore gateway are subsequently presented based on global and partitioned scheduling paradigms. We evaluate the WCRT results of two analysis methods with real message sets provided by the automaker, and present the design optimization guide.