Loading [a11y]/accessibility-menu.js
Prediction of circRNA-MiRNA Association Using Singular Value Decomposition and Graph Neural Networks | IEEE Journals & Magazine | IEEE Xplore

Prediction of circRNA-MiRNA Association Using Singular Value Decomposition and Graph Neural Networks


Abstract:

A large number of experimental studies have shown that circRNAs can act as molecular sponges of microRNAs, interacting with miRNAs to regulate gene expression levels, the...Show More

Abstract:

A large number of experimental studies have shown that circRNAs can act as molecular sponges of microRNAs, interacting with miRNAs to regulate gene expression levels, thereby affecting the development of human diseases. Exploring the potential associations between circRNAs and miRNAs can help understand complex disease mechanisms. Considering that biological experiments are time-consuming and labor-intensive, this study proposes a computational model using a graph neural network and singular value decomposition (CMASG) for circRNA-miRNA association prediction. Specifically, graph neural networks are used to learn nonlinear feature representations of nodes, followed by matrix factorization algorithms to learn linear feature representations of nodes, and then combined feature representations learned from different perspectives. Finally, the lightGBM algorithm was used for circRNA-miRNA association prediction. The proposed CMASG model achieved an AUC value of 0.8804. The experimental results demonstrate the superiority and effectiveness of the CMASG model in predicting circRNA-miRNA association tasks.
Page(s): 3461 - 3468
Date of Publication: 17 November 2022

ISSN Information:

PubMed ID: 36395130

Funding Agency:


References

References is not available for this document.