A newly developed point-to-point low voltage single-ended (PLS) signaling is proposed to improve transmission efficiency and to reduce the cost of high resolution and high frame rate flat panel displays for large size TV applications. This signaling can reduce the number of transmission lines by a half at same transmission speed in comparison with other existing interfaces. The source driver IC using proposed interface and hybrid 10-bit DAC have been fabricated in 0.35 mum CMOS process and the performance of the proposed signaling was verified by IC test using semiconductor parametric test equipment and inspection of image quality on 42-inch full HD TFT-LCD module for high-end TV models. Maximum operating frequency of the interface was 200 MHz at 0.6 Vpp and all channels of 10-bit DAC outputted exactly for 1024 gray scale.