Implementing flexible, software-defined duplexing transceivers remains challenging due to the inherent self-interference from TX to RX that requires cancellation in the RF/analog domain. Previously, we presented a novel, duplexing, integrated, single antenna transceiver architecture that used an M-stage distributed amplifier combined with an artificial transmission line to achieve high transmit-receive isolation across more than an octave in center frequency. In this paper, we explain and explore the trade-offs and limits on this class of distributed, duplexing transceivers as a function of system and sub-circuit parameters.