Due to the plethora of non-isolated high gain step-up dc-dc converters presented in the literature, it has become important to comprehensively review and classify them, as well as to derive methods to generalize the usage of the commonly employed techniques. Motivated by this need, this paper not only proposes a new family of high gain step up dc-dc converter, but a generalized methodology to derive them from any classical dc-dc topology by applying a coupled inductor and voltage multiplier cells. For illustrating the methodology, high gain dc-dc converters based on the basic topologies (Buck, Boost, and Buck-Boost) are developed and analyzed. These converters are compared in terms of voltage gain, coupled inductor size, voltage stresses, total device rating, switching frequency effect in power loss, and output power regulation. Moreover, in order to verify the proposal, two practical experimentations are accomplished. Firstly, a prototype able to operate as any of the three basic topologies with different gain cells is developed for comparing theoretical, simulated, and experimental static gain results. Secondly, well-designed prototypes concerning to the Buck-, Boost-, and Buck-Boost-based converters are assembled for efficiency evaluation.